## Abstract The efficient and rapid nucleophilic exchange of fluorine by fluoride‐^18^F ion in aromatic rings is reported here utilizing rubidium‐^18^F‐fluoride in DMSO on model compounds. Specific activities in the 3 × 10^4^ Ci/mol region are readily achievable. Nucleophilic substitution is shown
Fluorine-18 labelling of ortho-fluorohippuric acid by isotope exchange reaction
✍ Scribed by Ch. L. Ndiokwere
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 279 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The ^18^F‐labelling of o‐fluorohippuric acid by isotope exchange reactions has been studied in several organic solvents under varying reaction conditions. The solvent mixture ethanol/water (1:1) was found suitable for the isotope exchange reaction: a 100 per cent isotope exchange was observed for this system after an exchange time of one and half hours. No isotope exchange was observed in the molten state of the exchanging species.
📜 SIMILAR VOLUMES
## Abstract Fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers have been prepared by a facile ^18^F‐for‐^19^F isotopic exchange reaction. The isotopic exchange proceeds in good to excellent yields (up to 85%), and is dependent on reaction time, temperature, and concentration of reactant
## Abstract Sulbactam, a β‐lactamase inhibitor, has been prepared in tritiated (170 mCi mmol^−1^) form by the highly stereospecific isotope exchange procedure involving penicillanic acid (R)‐sulphoxide benzyl ester. The stereochemistry of the tritiation has been established by ^3^H n.m.r. in conjun
## Abstract Radioiodinated 5‐(1‐hydroxy‐2‐iodoethyl)‐2′‐deoxyuridine (1a) and 5‐(1‐methoxy‐2‐iodoethyl)‐2′‐deoxyuridine (2a) were prepared from the corresponding unlabelled nucleosides (1 and 2) by isotope exchange in a pivalic acid melt. Compound 1a was obtained in 71.3% to 26.3% radiochemical yie