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Synthesis of fluorine-18 labeled 1,1-difluoro-2,2-dichloroethyl aryl ethers by 18F-for-19F exchange

✍ Scribed by Michael R. Kilbourn; Raghu Subramanian

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
293 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Fluorine‐18 labeled 1,1‐difluoro‐2,2‐dichloroethyl aryl ethers have been prepared by a facile ^18^F‐for‐^19^F isotopic exchange reaction. The isotopic exchange proceeds in good to excellent yields (up to 85%), and is dependent on reaction time, temperature, and concentration of reactants (aryl ether or fluoride ion). Substitution even occurs at room temperature in DMSO, and at elevated temperature (100 to 155°C) in DMSO or acetonitrile containing up to 20% water. Specific activities of 0.5‐55 Ci/mol have been achieved, with the products obtained in pure radiochemical and chemical form.

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