✦ LIBER ✦

Fluorinated benzamide neuroleptics. 1. Radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(2[F-18]fluoroethyl)-2-methoxybenzamide: A potential fluorine-18 labeled PET radiotracer for dopamine D2 receptors

✍ Scribed by Jogeshwar Mukherjee; Bruce D. Perry; Malcolm Cooper

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 360 KB
Volume: 28
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580280511

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✦ Synopsis

Abstract

The synthesis of a tosylate precursor for the radiosynthesis of a potential PET radiotracer, (S)‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2‐[^18^F]fluoroethyl)‐2‐ methoxybenzamide is reported. Reaction of ^18^F‐fluoride with the tosylate provides the radiolabeled product in 10–25% yield. Specific activity of the radiotracer varied between 600–800 Ci/mmol after purification of the product mixture by reverse phase HPLC.

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