18F-labeled benzamide derivatives: Synthesis of 3,5-dichloro-N-[1-{2-[18F]-fluoroethyl}-2-pyrrolidinyl)methyl]-6-methoxysalicylamide And derivatives as dopamine D-2 receptor-binding radioligands

Fluorinated benzamide neuroleptics. 1. R

Fluorinated benzamide neuroleptics. 1. Radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(2[F-18]fluoroethyl)-2-methoxybenzamide: A potential fluorine-18 labeled PET radiotracer for dopamine D2 receptors

✍ Jogeshwar Mukherjee; Bruce D. Perry; Malcolm Cooper 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 360 KB

## Abstract The synthesis of a tosylate precursor for the radiosynthesis of a potential PET radiotracer, (S)‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2‐[^18^F]fluoroethyl)‐2‐ methoxybenzamide is reported. Reaction of ^18^F‐fluoride with the tosylate provides the radiolabeled product in 10–25% yield. S