✦ LIBER ✦
Determination of the stereochemistry of tritium label in sulbactam obtained by isotope exchange of penicillanic acid (R)-sulphoxide benzyl ester
✍ Scribed by Colin L. Gibson; John R. Jones; Andrew P. Sharratt; Robert H. Liss
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 268 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Sulbactam, a β‐lactamase inhibitor, has been prepared in tritiated (170 mCi mmol^−1^) form by the highly stereospecific isotope exchange procedure involving penicillanic acid (R)‐sulphoxide benzyl ester. The stereochemistry of the tritiation has been established by ^3^H n.m.r. in conjunction with a ^1^H NOESY spectrum of sulbactam.