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Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum

✍ Scribed by Andrea Küthe; Heike Eckel; Christian G. Stief; Stefan Ückert; Wolf G. Forssmann; Udo Jonas; Hans J. Mägert

Book ID
114009751
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
85 KB
Volume
119-120
Category
Article
ISSN
0009-2797

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✍ Gilberto De Nucci; Raquel Lorenzetti; Cristina E Okuyama; Juliana S Baracat; Jos 📂 Article 📅 2007 🏛 BioMed Central 🌐 English ⚖ 785 KB

## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by