✦ LIBER ✦
Pharmacological characterization of the novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum
✍ Scribed by Gilberto De Nucci; Raquel Lorenzetti; Cristina E Okuyama; Juliana S Baracat; José L Donato; Edson Antunes; Cleber E Teixeira
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 785 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
No coin nor oath required. For personal study only.
✦ Synopsis
Background
Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by inhibiting cGMP breakdown.