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Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells

โœ Scribed by Robert B. Moreland; Irwin Goldstein; Abdulmaged Traish


Book ID
117175669
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
808 KB
Volume
62
Category
Article
ISSN
0024-3205

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## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by