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MP-12.11: Pharmacological characterization of the novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum

โœ Scribed by G. De Nucci; R. Lorenzetti; C.E. Okuyama; J.S. Baracat; J.L. Donato; E. Antunes; C.E. Teixeira


Book ID
116948109
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
97 KB
Volume
70
Category
Article
ISSN
0090-4295

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Pharmacological characterization of the
โœ Gilberto De Nucci; Raquel Lorenzetti; Cristina E Okuyama; Juliana S Baracat; Jos ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› BioMed Central ๐ŸŒ English โš– 785 KB

## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by