Pharmacological characterization of the
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Gilberto De Nucci; Raquel Lorenzetti; Cristina E Okuyama; Juliana S Baracat; Jos
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Article
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2007
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BioMed Central
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English
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## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by