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Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases

✍ Scribed by Peng Wang; Ping Wu; Joyce G. Myers; Andrew Stamford; Robert W. Egan; M.Motasim Billah

Book ID
117172856
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
139 KB
Volume
68
Category
Article
ISSN
0024-3205

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## Background Nitrergic nerves and endothelial cells release nitric oxide (NO) in the corpus cavernosum (CC), a key mediator that stimulates soluble guanylyl cyclase to increase cGMP levels and cause penile erection. Phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, prolong NO effects by