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Methoxyethoxymethyl group for the protection of uracil residue in oligoribonucleotide synthesis

✍ Scribed by Hiroshi Takaku; Souichi Ueda; Tsunehiko Ito


Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
295 KB
Volume
24
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


(Butylthio)carbonyl Group: A New Protect
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The protection of the 06-amide and N2-amino groups of guanosine with the (butylthio)carbonyl group is described. This group could be rapidly introduced in good yields and removed very easily under the conventional deprotective condition for the exo-amino acyl groups of other nucleoside bases.

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The protection of uracil and 2-E-acyl guanine residues with 4-G-phenyl [or 4-c-(2,4dimethylphenyl)] and 6-g-(Z-nitrophenyl) groups as in 7a [or 7bl and 2, respectively, is described. These g-aryl protecting groups, which appearto withstand the usual conditions of oligonucleotide synthesis, may rea

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The 1-~(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl [Ctmp, as in (14a)] has an acid lability similar to that of the 4-methoxytetrahydropyran-4-yl (Mthp) protect= group under mild hydrolytic conditions [pH 2-31; however, under the relatively more drastic conditions required for the complete rem