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An acetal group suitable for the protection of 2′-hydroxy functions in rapid oligoribonucleotide synthesis

✍ Scribed by Colin B Reese; Halina T Serafinowska; Giovanni Zappia

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
260 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

The 1-~(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl [Ctmp, as in (14a)] has an acid lability similar to that of the 4-methoxytetrahydropyran-4-yl (Mthp) protect= group under mild hydrolytic conditions [pH 2-31; however, under the relatively more drastic conditions required for the complete removal of a 9-phenylxanthen-9-yl (Px) group, the Ctmp protecting group remains virtually intact.

The 4-methoxytetrahydropyran-4-yl [Mthp, as in (L)] group1 has proved 293 to be particu-

📜 SIMILAR VOLUMES

Nucleotides, Part LXVIII , Acetals as Ne
Nucleotides, Part LXVIII , Acetals as New 2′-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Monomeric Building Units and Oligoribonucleotides
✍ Stefan Matysiak; Wolfgang Pfleiderer 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 German ⚖ 232 KB 👁 2 views

For the efficient synthesis of oligoribonucleotides by the 5'-O-(4,4'-dimethoxytrityl) phosphoramidite approach, the 2'-O-[1-(benzyloxy)ethyl]acetals 56 ± 67 were investigated. Studies with the 2'-O-[1-(benzyloxy)ethyl]-5'-O-(dimethoxytrityl)ribonucleoside 3'-phosphoramidites 56 ± 59 gave, however,

ChemInform Abstract: Nucleotides. Part 6
ChemInform Abstract: Nucleotides. Part 68. Acetals as New 2′-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Monomeric Building Units and Oligoribonucleotides.
✍ Stefan Matysiak; Wolfgang Pfleiderer 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

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