𝔖 Bobbio Scriptorium
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1-(2-Chloroethoxy)ethyl group for the protection of 2′-hydroxyl group in the synthesis of oligoribonucleotides

✍ Scribed by Shun-ichi Yamakage; Osamu Sakatsume; Eiichi Furuyama; Hiroshi Takaku

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
296 KB
Volume
30
Category
Article
ISSN
0040-4039

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An acetal group suitable for the protect
An acetal group suitable for the protection of 2′-hydroxy functions in rapid oligoribonucleotide synthesis
✍ Colin B Reese; Halina T Serafinowska; Giovanni Zappia 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 260 KB

The 1-~(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl [Ctmp, as in (14a)] has an acid lability similar to that of the 4-methoxytetrahydropyran-4-yl (Mthp) protect= group under mild hydrolytic conditions [pH 2-31; however, under the relatively more drastic conditions required for the complete rem