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ChemInform Abstract: Nucleotides. Part 68. Acetals as New 2′-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Monomeric Building Units and Oligoribonucleotides.

✍ Scribed by Stefan Matysiak; Wolfgang Pfleiderer


Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
32
Category
Article
ISSN
0931-7597

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Abstract

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Nucleotides, Part LXVIII , Acetals as Ne
✍ Stefan Matysiak; Wolfgang Pfleiderer 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 German ⚖ 232 KB 👁 2 views

For the efficient synthesis of oligoribonucleotides by the 5'-O-(4,4'-dimethoxytrityl) phosphoramidite approach, the 2'-O-[1-(benzyloxy)ethyl]acetals 56 ± 67 were investigated. Studies with the 2'-O-[1-(benzyloxy)ethyl]-5'-O-(dimethoxytrityl)ribonucleoside 3'-phosphoramidites 56 ± 59 gave, however,