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The protection of uracil and guanine residues in oligonucleotide synthesis

✍ Scribed by Simon S. Jones; Colin B. Reese; Samson Sibanda; Aiko Ubasawa

Publisher: Elsevier Science
Year: 1981
Tongue: French
Weight: 272 KB
Volume: 22
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)83032-x

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✦ Synopsis

The protection of uracil and 2-E-acyl guanine residues with 4-G-phenyl [or 4-c-(2,4dimethylphenyl)]

and 6-g-(Z-nitrophenyl) groups as in 7a [or 7bl and 2, respectively, is described.

These g-aryl protecting groups, which appearto withstand the usual conditions of oligonucleotide synthesis, may readily be removed by treatment with 2-nitrobenzaldoximate ions.

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