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Necessary protection of the O6-position of guanine during the solid phase synthesis of oligonucleotides by the phosphoramidite approach

✍ Scribed by Richard T. Pon; Masad J. Damha; Kelvin K. Ogilvie

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 227 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)98827-0

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✦ Synopsis

It has been observed that the use of U6-protected deoxyguanosine phosphoramidites leads to a significant improvement in the automated synthesis of oligonucleotides on an insoluble support.

The introduction of deoxyribonucleoside-3'-phosphoKamidite derivatives by

Caruthers and Beaucagel has lead to the routine synthesis of short oligonucleo-

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