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Preparation of ribonucleoside 3′-O-phosphoramidites and their application to the automated solid phase synthesis of oligonucleotides

✍ Scribed by Nassim Usman; Richard T. Pon; Kelvin K. Ogilvie

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 247 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)98753-7

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✦ Synopsis

Oligoribonucleotides, six to fifteen units long, were synthesized on a controlled pore glass support using ribonucleoside 3'-0-phosphoramidite reagents. Average coupling yieids of up to 98% were obtained with dirsopropylamrnophosphoramidite derivatives.

In light of the increasing interest in the role of RNA in molecular biology (for example its involvement in the self-splicing of pre-rRNA transcripts2, the emergence of recombinant RNA technology3, as well as the known role of transfer

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