For the efficient synthesis of oligoribonucleotides by the 5'-O-(4,4'-dimethoxytrityl) phosphoramidite approach, the 2'-O-[1-(benzyloxy)ethyl]acetals 56 ± 67 were investigated. Studies with the 2'-O-[1-(benzyloxy)ethyl]-5'-O-(dimethoxytrityl)ribonucleoside 3'-phosphoramidites 56 ± 59 gave, however,
Nucleotides, Part LX , Synthesis and Characterization of New 2′-O-Methylriboside 3′-O-Phosphoramidites Useful for the Solid-Phase Synthesis of 2′-O-Methyloligoribonucleotides
✍ Scribed by Hagen Cramer; Wolfgang Pfleiderer
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- German
- Weight
- 282 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0018-019X
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Table . Selected physical data of compounds 2, 3, 10, 12, and 14-17. 2: M.P. 143°C; [ x ] ~ = -25.1 (C = 0.6, CHCI,); 'H NMR (CDCI,, TMS): 6 = 5.13 ( S , 5 1 . 2 = 0, 1 H ; HI); "C NMR (CDCI,, TMS): 6 = 96.2 (CI), 76.1, 75.8, 75.0 (C2,3,4). 69.3 (Bn), 64.3 (C5). 17.1 (C6). 3: M.P. 117-118°C; [alD =