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Preparation of glyceronucleoside phosphoramidite synthons and their use in the solid phase synthesis of acyclic oligonucleotides

✍ Scribed by Nassim Usman; Carl D. Juby; Kelvin K. Ogilvie

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 293 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80620-6

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✦ Synopsis

The syntheses of N,N-diisopropylmethylphosphoramidites (3a,b) of 9-I [Zdimethoxytrityl-hydroxy-l-(hydroxymethyl)ethoxy]-methyl)N6-benzoyladenine, 2a, and l-{ [Zdimethoxytritylhydroxy-1-(hydroxymethyl)ethoxy]-methyl)thymine, 2b, are described. Oligoacyclonucleotides, 2 -8 units long, were synthesized using these synthons on either controlled pore glass or silica gel

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