Nucleosides, Part LXIV , Base-Labile Protecting Groups for the Oligoribonucleotide Synthesis
✍ Scribed by Ursula Münch; Wolfgang Pfleiderer
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- German
- Weight
- 144 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0018-019X
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📜 SIMILAR VOLUMES
For the efficient synthesis of oligoribonucleotides by the 5'-O-(4,4'-dimethoxytrityl) phosphoramidite approach, the 2'-O-[1-(benzyloxy)ethyl]acetals 56 ± 67 were investigated. Studies with the 2'-O-[1-(benzyloxy)ethyl]-5'-O-(dimethoxytrityl)ribonucleoside 3'-phosphoramidites 56 ± 59 gave, however,
The amino functions of the common 2'-deoxyribo-and ribonucleosides were blocked by the (2cyanoethoxy)carbonyl group on treatment with 2-cyanoethyl carbonochloridate (5) or 1-[(2-cyanoethoxy)carbonyl]-3-methyl-1H-imidazolium chloride (6) leading to 7, 18, 8, 19, 9, and 20. In 2'-deoxyguanosine, the a