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Loss of heterozygosity in human ductal breast tumours indicates a recessive mutation on chromosome 13

✍ Scribed by Lundberg, Catharina; Skoog, Lambert; Nordenskjöld, Magnus


Book ID
123534169
Publisher
Elsevier Science
Year
1987
Weight
119 KB
Volume
23
Category
Article
ISSN
0277-5379

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The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation wit