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Loss of constitutional heterozygosity on chromosomes 17, 13 and 11 in human breast cancer

✍ Scribed by I. Vořechovský; G.R.M. White; C. Rackstraw; M. Santibanez-Koref


Book ID
113252512
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
86 KB
Volume
271
Category
Article
ISSN
0165-1161

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The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation wit