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High rates of loss of heterozygosity on chromosome 19p13 in human breast cancer

✍ Scribed by Oesterreich, S; Allredl, D C; Mohsin, S K; Zhang, Q; Wong, H; Lee, A V; Osborne, C K; O'Connell, P


Book ID
119981082
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
115 KB
Volume
84
Category
Article
ISSN
0007-0920

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The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation wit