Loss of heterozygosity on chromosome 7q31 in breast cancer
✍ Scribed by A. Cooke; Y.T. Kim; T.I. Harvey; J.M. Connor; J. Nagy; W.D. George
- Book ID
- 119065935
- Publisher
- The Lancet
- Year
- 1993
- Tongue
- English
- Weight
- 172 KB
- Volume
- 341
- Category
- Article
- ISSN
- 0140-6736
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One of the main genetic abnormalities associated with breast carcinogenesis is the loss of genetic material from chromosome arm 16q. Different groups have identified two regions (16q22.1 and 16q24-ter) that are frequently deleted in primary tumors, suggesting the presence of tumor suppressor genes i
Although human breast tumorigenesis is associated with the accumulation of mutations both in oncogenes and in tumor suppressor genes, the identity of the genetic alterations that are critical in the early stages of the breast tumorigenic process remains obscure. A high frequency (27-41%) of loss of