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452 Loss of heterozygosity on 7Q31 occurs early during breast tumorigenesis

✍ Scribed by M.H. Champème; I. Bièche; M. Beuzelin; R. Lidereau

Book ID
116167206
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
161 KB
Volume
31
Category
Article
ISSN
0959-8049

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Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis
✍ Marie-Hélène Champème; Ivan Bièche; Michèle Beuzelin; Rosette Lidereau 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

Although human breast tumorigenesis is associated with the accumulation of mutations both in oncogenes and in tumor suppressor genes, the identity of the genetic alterations that are critical in the early stages of the breast tumorigenic process remains obscure. A high frequency (27-41%) of loss of