Loss of Heterozygosity on Chromosome 1q in Human Breast Cancer
β Scribed by Ling-Chun Chen, Charles Dollbaum and Helene S. Smith
- Book ID
- 123637166
- Publisher
- National Academy of Sciences
- Year
- 1989
- Tongue
- English
- Weight
- 835 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/34429
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π SIMILAR VOLUMES
One of the main genetic abnormalities associated with breast carcinogenesis is the loss of genetic material from chromosome arm 16q. Different groups have identified two regions (16q22.1 and 16q24-ter) that are frequently deleted in primary tumors, suggesting the presence of tumor suppressor genes i
The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation wit