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Refined mapping of the region of loss of heterozygosity on the long arm of chromosome 7 in human breast cancer defines the location of a second tumor suppressor gene at 7q22 in the region of the CUTL1 gene

✍ Scribed by Zeng, Wendy Rong; Watson, Peter; Lin, Jenny; Jothy, Serge; Lidereau, Rosette; Park, Morag; Nepveu, Alain


Book ID
110061966
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
194 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract Loss of heterozygosity (LOH) on 8p occurs at high frequencies in many tumor types, including colorectal carcinoma (CRC). We previously used microcell‐mediated chromosome transfer (MMCT) into the CRC cell line SW620 to map a ∼7.7‐Mb colorectal cancer–suppressor region (CRCSR) at 8p22–23.