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Loss of Heterozygosity on Chromosome 13q: Suggestion of a Candidate Tumor Suppressor Gene in Sporadic Breast Cancer

✍ Scribed by Dan Tong; Eva Schuster; Klaus Czerwenka; Sepp Leodolter; Robert Zeillinger

Book ID: 111574990
Publisher: Springer US
Year: 2004
Tongue: English
Weight: 101 KB
Volume: 83
Category: Article
ISSN: 0167-6806
DOI: 10.1023/b:brea.0000010707.83796.31

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## Abstract Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome‐wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylate