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Patterns of loss of heterozygosity at loci from chromosome arm 13q suggest a possible involvement of BRCA2 in sporadic breast tumors

✍ Scribed by Fabienne Kerangueven; Florence Allione; Teburo Noguchi; José Adélaïde; Hagay Sobol; Jocelyne Jacquemier; Daniel Birnbaum

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
363 KB
Volume
13
Category
Article
ISSN
1045-2257

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✦ Synopsis

Loss of heterozygosity (LOH) at loci from chromosome I3 is frequently observed in breast cancer. Chromosome I3 contains at least two cancer genes, the well-characterized RBI gene located at 13q 14 and the breast cancer-susceptibility gene, BRCAZ, recently localized to 13q 12. To investigate the possible involvement of BRCA2 in sporadic breast tumors, we looked at LOH at eight microsatellite (CA)" markers distributed along chromosome I3 in a panel of 59 primary breast carcinomas. We show that some LOH does not include the RBI locus and is associated with the BRCAZ gene region. Genes Chromosom Cancer

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✍ Florence Allione; François Eisinger; Patricia Parc; Tetsuro Noguchi; Hagay Sobol 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 196 KB 👁 2 views

Forty-four breast carcinomas were studied for loss of heterozygosity (LOH) at 25 microsatellite markers distributed almost evenly along chromosome arm 22q. LOH at at least one marker were observed in 66% tumors, while 6 regions of consistent LOH were identified. The size of each region ranged betwee