High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers
β Scribed by Eiriksdottir, Gudny; Barkardottir, Rosa B; Agnarsson, Bjarni A; Johannesdottir, Gudrun; Olafsdottir, Kristrun; Egilsson, Valgardur; Ingvarsson, Sigurdur
- Book ID
- 110061078
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 397 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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Loss of heterozygosity (LOH) at loci from chromosome I3 is frequently observed in breast cancer. Chromosome I3 contains at least two cancer genes, the well-characterized RBI gene located at 13q 14 and the breast cancer-susceptibility gene, BRCAZ, recently localized to 13q 12. To investigate the poss
## Abstract Sixty DNA samples from breast carcinoma (BC) patients were analyzed by Southern blot to examine certain oncogene and antiβoncogene alterations. Amplification of the HERβ2 oncogene was detected in 15 tumours (25%), cβmyc in 2 (3%) only and HERβ1 in none. Distribution of Hrasβ1 oncogene a