Interaction of cis-diamminedichloroplatinum (II) with phosphate carrier in mitochondria
✍ Scribed by Tkáčová, Eva; Kuẑela, Štefan
- Book ID
- 122725673
- Publisher
- Elsevier Science
- Year
- 1985
- Weight
- 80 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0277-5379
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## Abstract The interactions of the ribonucleotide poly C with __cis__‐ and __trans__‐diamminedichloroplatinum (II) were probed with Raman spectroscopy. Both platinum compounds attack the __N__‐1 position of the cytosine residue, while the __trans__ form appears to attack the PO~2~^−^ as well. Rama
DNA samples isolated from control nuclei and nuclei treated by cis-and trans-diamminedichloroplatinum (DDP) were analyzed by gel electrophoresis. There were no changes in Mr when DNA isolated from nuclei treated with trans-DDP was analyzed. Scans of DNA isolated from nuclei treated with cis-DDP reve