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Interaction of poly C with cis- and trans-diamminedichloroplatinum (II): Secondary structure effects

✍ Scribed by Dennis P. Strommen; Warner L. Peticolas

Publisher: Wiley (John Wiley & Sons)
Year: 1982
Tongue: English
Weight: 450 KB
Volume: 21
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360210509

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✦ Synopsis

Abstract

The interactions of the ribonucleotide poly C with cis‐ and trans‐diamminedichloroplatinum (II) were probed with Raman spectroscopy. Both platinum compounds attack the N‐1 position of the cytosine residue, while the trans form appears to attack the PO~2~^−^ as well. Raman difference spectra obtained from samples of poly C containing similar amounts of the respective Pt compounds indicate that the trans form is able to disrupt the secondary structure of poly C to a greater degree than the cis form. This latter observation may be a contributing factor in the low therapeutic index exhibited by the trans form.

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