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DNA degradation after interaction of cis- and trans-diamminedichloroplatinum (II) with calf thymus nuclei

✍ Scribed by R. Oliński

Publisher: Springer
Year: 1986
Tongue: English
Weight: 230 KB
Volume: 11
Category: Article
ISSN: 0301-4851
DOI: 10.1007/bf00417591

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✦ Synopsis

DNA samples isolated from control nuclei and nuclei treated by cis-and trans-diamminedichloroplatinum (DDP) were analyzed by gel electrophoresis. There were no changes in Mr when DNA isolated from nuclei treated with trans-DDP was analyzed. Scans of DNA isolated from nuclei treated with cis-DDP revealed significant changes in Mr. This DNA bears, however, no signs of regular fragmentation. The possible involvement of endonuclease activity in the degradation process is discussed.

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