Interaction of cis- and trans-diamminedichloroplatinum with metallothionein in vivo
β Scribed by Baolin Zhang; Hui Huang; Wenxia Tang
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 487 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0162-0134
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## Abstract The interactions of the ribonucleotide poly C with __cis__β and __trans__βdiamminedichloroplatinum (II) were probed with Raman spectroscopy. Both platinum compounds attack the __N__β1 position of the cytosine residue, while the __trans__ form appears to attack the PO~2~^β^ as well. Rama
The cytotoxicity of the topoisomerase-I inhibitors, camptothecin and topotecan, toward the SCC-25 human head-andneck squamous-carcinoma cells and the SCC-25/CDDP sub-line made resistant to cis-diamminedichloroplatinum(ll) was assessed alone and in combination with radiation. Topotecan was less cytot