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Inhibitors of sterol synthesis. Studies of the distribution and metabolism of 5α-[2,4−3H] cholest-8(14)-en-3β-ol-15-one after intragastric administration to rats

✍ Scribed by John S. Brabson; George J. Schroepfer Jr.


Book ID
116065335
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
892 KB
Volume
52
Category
Article
ISSN
0039-128X

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Inhibitors of sterol synthesis. Synthesi
✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy