Inhibitors of sterol synthesis. Oleate ester of 5α-cholest-8(14)-en-3β-ol-15-one as a substrate for pancreatic cholesterol esterase
✍ Scribed by Thomas W. Stephens; George J. Schroepfer Jr.
- Book ID
- 115740122
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 645 KB
- Volume
- 963
- Category
- Article
- ISSN
- 0005-2760
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## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy
The effects of dietary administration (0.1070 in diet for 8 days) of 5t~-cholest-8( )-en-3/I-ol-15-one on the levels of activity of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, and microsomal HMG-CoA reductase in liver have been studied in male