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Inhibition of hepatic sterol synthesis and reduction of serum cholesterol in rats by 5α-cholest-8(14)-en-3β-ol-15-one

✍ Scribed by Dwight L. Raulston; Clifford O. Mishaw; Edward J. Parish; George J. Schroepfer Jr.

Book ID
118310842
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
267 KB
Volume
71
Category
Article
ISSN
0006-291X

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## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy