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Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-c-d ring junction—5α, 14β-Cholest-7-en-15α-ol-3-one and 5α, 14β-Cholest-7-en-15β-ol-3-one

✍ Scribed by George J. Schroepfer Jr.; Robert A. Pascal Jr.; Andrew A. Kandutsch

Book ID
115774739
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
435 KB
Volume
28
Category
Article
ISSN
0006-2952

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Sterol synthesis. Synthesis of 15-oxygen
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Inhibitors of sterol synthesis. Synthesi
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✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy