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Sterol synthesis. Synthesis of 15-oxygenated 5α, 14β-cholest-7-en-3β-ol derivatives

✍ Scribed by Edward J. Parish; George J. Schroepfer Jr.

Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
918 KB
Volume
19
Category
Article
ISSN
0009-3084

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✦ Synopsis

Treatment of 3~.benzoyloxy-140, 15wepoxy-5(~.cholesg-7-ene with boron trifluoride-etherate 8ave, in 43% yield, 30-benzoyloxy-Sa, 14~cholest-7-en,15-one with the unnatt~ral C-D ring juncture, Reduction of the latteg compound with lithium aluminum hydride gave 15a, 14O-~holest-7.en'3p, 15wdiol and 5~, 14pcholest-7-en-3#, 15~-cliol in 9% and 81% yields, ~espectively.

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