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Inhibition of sterol synthesis in L cells by 14α-ethyl-5α-cholest-7-en-15α-ol-3-one at nanomolar concentrations

✍ Scribed by George J. Schroepfer Jr.; Dwight L. Raulston; Andrew A. Kandutsch


Book ID
118311343
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
295 KB
Volume
79
Category
Article
ISSN
0006-291X

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📜 SIMILAR VOLUMES


Sterol synthesis. Synthesis of 15-oxygen
✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1977 🏛 Elsevier Science 🌐 English ⚖ 918 KB

Treatment of 3~.benzoyloxy-140, 15wepoxy-5(~.cholesg-7-ene with boron trifluoride-etherate 8ave, in 43% yield, 30-benzoyloxy-Sa, 14~cholest-7-en,15-one with the unnatt~ral C-D ring juncture, Reduction of the latteg compound with lithium aluminum hydride gave 15a, 14O-~holest-7.en'3p, 15wdiol and 5~,

Inhibitors of sterol synthesis. Synthesi
✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy