Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 9α-Fluoro-5α-cholest-8(14)-en-3β-ol-15-one
✍ Scribed by George J. Schroepfer Jr.; Vernoy Nalker; Edward J. Parish; Alemka Kisic
- Book ID
- 118314808
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 302 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy
Treatment of 3~.benzoyloxy-140, 15wepoxy-5(~.cholesg-7-ene with boron trifluoride-etherate 8ave, in 43% yield, 30-benzoyloxy-Sa, 14~cholest-7-en,15-one with the unnatt~ral C-D ring juncture, Reduction of the latteg compound with lithium aluminum hydride gave 15a, 14O-~holest-7.en'3p, 15wdiol and 5~,
The effects of dietary administration (0.1070 in diet for 8 days) of 5t~-cholest-8( )-en-3/I-ol-15-one on the levels of activity of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, and microsomal HMG-CoA reductase in liver have been studied in male