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Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5α-cholest-8(14)-en-3β-ol-15-one in rats and mice

✍ Scribed by George J. Schroepfer Jr.; Daniel Monger; Allan S. Taylor; Jeffrey S. Chamberlain; Edward J. Parish; Alemka Kisic; Andrew A. Kandutsch

Book ID
118311948
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
380 KB
Volume
78
Category
Article
ISSN
0006-291X

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Inhibitors of sterol synthesis. Synthesi
Inhibitors of sterol synthesis. Synthesis of [2,4-3H]5α-cholest-8(14)-ene-3β,7α,15α-triol and [2,4-3H]5α-cholest-8(14)-en-38-ol-15-one
✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy

Inhibitors of sterol synthesis. Effects
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✍ Larry R. Miller; Dwight L. Raulston; George J. Schroepfer Jr. 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 704 KB

The effects of dietary administration (0.1070 in diet for 8 days) of 5t~-cholest-8( )-en-3/I-ol-15-one on the levels of activity of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, and microsomal HMG-CoA reductase in liver have been studied in male