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Inhibitors of sterol synthesis. Dietary administration of 5α-cholest-8(14)-en-3β-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats

✍ Scribed by George J. Schroepfer Jr.; Armand Christophe; Dolores H. Needleman; Alemka Kisic; Bette C. Sherrill

Book ID
115760453
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
333 KB
Volume
146
Category
Article
ISSN
0006-291X

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## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy