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Inhibitors of sterol synthesis. Exogenous oleate reduces the inhibitory effect of 5α-Cholest-8(14)-en-3β-ol-15-one on the growth of CHO-K1 cells

✍ Scribed by Frederick D. Pinkerton; Nanda Duhe Kirkpatrick; George J. Schroepfer Jr.

Book ID
117058353
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
297 KB
Volume
156
Category
Article
ISSN
0006-291X

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Inhibitors of sterol synthesis. Synthesis of [2,4-3H]5α-cholest-8(14)-ene-3β,7α,15α-triol and [2,4-3H]5α-cholest-8(14)-en-38-ol-15-one
✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy