Inhibition of murine cytomegalovirus lung infection and interstitial pneumonitis by acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine.
β Scribed by Shanley, J D; Morningstar, J; Jordan, M C
- Book ID
- 124051545
- Publisher
- American Society for Microbiology
- Year
- 1985
- Tongue
- English
- Weight
- 750 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0066-4804
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## Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3β4 days and die at 6β9 days after the infection. 9β(1,3βDihydroxyβ2βpropoxyrnethyl)guanine (DHPG, ganciclovir) and (__S__)β1β(3βhydroxyβ2βpho
The acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) is a potent inhibitor of human cytomegalovirus in vitro and in vivo. In order to investigate the phosphorylation of DHPG to the monophosphate and identify the enzyme responsible, attempts were made to isolate DHPG kinase from cal