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Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG)

✍ Scribed by Johan Neyts; Robert Snoeck; Dominique Schols; Jan Balzarini; Erik De Clercq


Book ID
113209276
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
993 KB
Volume
179
Category
Article
ISSN
0042-6822

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πŸ“œ SIMILAR VOLUMES


Efficacy of (S)-1-(3-hydroxy-2-phosphony
✍ Johan Neyts; Jan Balzarini; Lieve Naesens; Erik de Clercq πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 540 KB

## Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and (__S__)‐1‐(3‐hydroxy‐2‐pho