Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

✍ Scribed by Johan Neyts; Jan Balzarini; Lieve Naesens; Erik de Clercq

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 540 KB
• Volume: 37
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890370112

✦ Synopsis

Abstract

Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and (S)‐1‐(3‐hydroxy‐2‐phosphonylrnethoxypropyl) cytosine (HPMPC) were compared for their efficacy against MCMV‐induced disease and mortality in SCID mice. Under all treatment conditions, i.e., administration of the test compounds for 5 consecutive days starting on the day of infection (day 0), for 5 consecutive days starting on day 4 after the infection, 2 periods of 3 consecutive days starting on day 0 and day 9 after infection, or as a single dose on day 3 before infection, HPMPC proved far superior to ganciclovir in delaying the onset of the disease and increasing the lifespan of the MCMV‐infected mice. © 1992 Wiley‐Liss, Inc.