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Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl) guanine and acyclovir in herpes simplex virus-infected and uninfected cells

✍ Scribed by Donald F. Smee; Richard Boehme; Marlene Chernow; Bridget P. Binko; Thomas R. Matthews


Book ID
115778495
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
644 KB
Volume
34
Category
Article
ISSN
0006-2952

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Efficacy of (S)-1-(3-hydroxy-2-phosphony
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## Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and (__S__)‐1‐(3‐hydroxy‐2‐pho