Generalized cytomegalovirus (CMV) infection and CMV-induced pneumonitis in the rat: Combined effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine and specific antibody treatment

Efficacy of (S)-1-(3-hydroxy-2-phosphony

Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

✍ Johan Neyts; Jan Balzarini; Lieve Naesens; Erik de Clercq 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

## Abstract Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytornegalovirus (MCMV) develop a wasting syndrome at 3–4 days and die at 6–9 days after the infection. 9‐(1,3‐Dihydroxy‐2‐propoxyrnethyl)guanine (DHPG, ganciclovir) and (__S__)‐1‐(3‐hydroxy‐2‐pho