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Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2′-fluoropyrimidine nucleosides

✍ Scribed by Donald F. Smee; Nancy L. Campbell; Thomas R. Matthews


Book ID
118260795
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
406 KB
Volume
5
Category
Article
ISSN
0166-3542

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Interaction of 9-(1,3-dihydroxy-2-propox
✍ Donald F. Smee 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 504 KB

The acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) is a potent inhibitor of human cytomegalovirus in vitro and in vivo. In order to investigate the phosphorylation of DHPG to the monophosphate and identify the enzyme responsible, attempts were made to isolate DHPG kinase from cal